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Triamterene may pass into breast milk and could cause harm to a nursing baby. Symptoms of a triamterene overdose may include increased urination, nausea, vomiting, weakness, fever, warmth or flushing in your face, or muscle spasms. {51} {52} Amiloride and triamterene have a direct inhibitory effect on the entry of sodium into the cells, while spironolactone competitively inhibits the action of aldosterone. OcularOcular side effects including acute transient myopia with shallowing of the anterior chamber has rarely been associated with HCTZ-triamterene, HCTZ, chlorthalidone, trichlormethiazide, and other sulfonamides, as well as aspirin, ethoxzolamide and acetazolamide. A case of cholestatic jaundice and centrolobular necrosis of the liver has been associated with triamterene (probably related to hypersensitivity to the drug).

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